反应详情

10% Palladium on carbon (10 mg, 0.892 mmol) was added to 2-morpholino-5-nitrophenol (prepared as described herein above; 200 mg, 0.892 mmol) in ethanol (20 mL), hydrogen gas was added (40 psi), and the reaction allowed to proceed for 12 h at room temperature. The reaction was monitored by TLC. After completion of the reaction, the reaction mixture filtered through Celite®, and the solvent removed in vacuo. The residue was purified by flash column chromatography (2% CH3OH/CH2Cl2) to provide the title compound 5-amino-2-morpholinophenol (200 mg, 0.937 mmol, 105% yield) as a solid.

1. additionwas added (40 psi)
2. customAfter completion of the reaction
3. filtrationthe reaction mixture filtered through Celite®
4. customthe solvent removed in vacuo
5. customThe residue was purified by flash column chromatography (2% CH3OH/CH2Cl2)