Hydrochloric Acid → HCID 90202440, compound

Participants

Reaction Conditions

Reaction Steps

Crude 3-[5-(2-Chloro-benzyloxy)-pyridin-2-yl]-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 9; 236 mg, 0.66 mmol assumed) was taken up in a mixture of 2 M KOH (12 mL) and THF (3 mL). The mixture was heated at 55° C. for 4 h and then stirred at room temperature overnight. The mixture was cooled to 0° C. and 4 M aqueous HCl (3 mL) was added. The mixture was extracted with EtOAc and the organic layer was dried (Na2SO4), filtered, and evaporated to give 3-[5-(2-chloro-benzyloxy)-pyridin-2-yl]-isoxazole-5-carboxylic acid (220 mg, 100%) as an off-white powder.

Provenance & Evidence