3-(Bromomethyl)-2-chloropyridine → 3-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

Participants

Reaction Steps

3-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 1) and 3-bromomethyl-2-chloro-pyridine (which may be prepared as described in Selby, T. P. and Winters, M. P. U.S. Pat. No. 5,739,326 Column 19) were reacted using conditions similar to those described for Preparation of Intermediate 24 to give 3-[4-(2-chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester.

Provenance & Evidence