Ammonia → HCID 90202338, compound

Participants

Reaction Steps

3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 12; 500 mg, 1.4 mmol) was dissolved in a saturated solution of NH3 in EtOH (200 mL). The mixture was stirred at room temperature for 60 h. The solvent was evaporated and the residue was purified by chromatography (50-60% EtOAc/hexanes) to give 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-isoxazole-5-carboxylic acid amide (160 mg, 35%) as a white solid.

Provenance & Evidence