Sodium Hydroxide → HCID 131735127, compound

Participants

Reaction Steps

4-(2-Trifluoromethyl-benzyloxy)-benzaldehyde (which may be prepared as described in Panetta, J. A. et al. U.S. Pat. No. 6,251,928 Column 25; 28.8 g, 102.7 mmol) was combined with 9:1 EtOH/H2O (210 mL) and hydroxylamine hydrochloride (11 g, 158 mmol) was added. A solution of 3.15 M NaOH in 9:1 EtOH/H2O (70 mL, 221 mmol) was added dropwise. The mixture was stirred at room temperature for 2 h and then heated at 50° C. for 1 h. The mixture was partitioned between EtOAc and H2O, and the organic layer was dried, filtered, and evaporated to give 4-(2-trifluoromethyl-benzyloxy)-benzaldehyde oxime (14 g, 46%).

Provenance & Evidence