Potassium Carbonate → HCID 76281324, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-(4-bromomethyl-phenyl)-isoxazole-5-carboxylic acid amide (which may be prepared as described in Preparation of Intermediate 14; 30 mg, 0.107 mmol) in CH3CN (2 mL) were added 2-hydroxybenzotrifluoride (29 mg, 0.179 mmol) and K2CO3 (30 mg, 0.22 mmol). The mixture was heated at 90° C. for 16 h and then evaporated to dryness. The residue was purified by chromatography (66-75% EtOAc/hexanes) to give 3-[4-(2-trifluoromethyl-phenoxymethyl)-phenyl]-isoxazole-5-carboxylic acid amide (30 mg, 77%) as a white powder. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.39 (s, 1H), 8.02 (s, 1H), 7.94 (d, J=8.5 Hz, 2H), 7.54-7.68 (m, 5H), 7.34 (d, J=8.5 Hz, 1H), 7.10 (t, J=7.7 Hz, 1H), 5.35 (s, 2H).

Provenance & Evidence