Lithium Hydroxide → HCID 178452942, compound

Participants

Reaction Steps

To diethyl(1R,2S,4S,5R,6R)-2-tert-butoxycarbonylamino-4-(1H-[1,2,4]triazol-3-ylsulfanyl)-bicyclo[3.1.0]hexane-2,6-dicarboxylate (1.9 g, 4.31 mmol) in tetrahydrofuran (20 mL) add 2.5M aqueous solution lithium hydroxide (20.70 mL, 51.76 mmol) and stir at room temperature overnight. Evaporate the tetrahydrofuran. Dilute with water and wash with ethyl acetate. Discard the organic layer. Adjust aqueous phase to pH=2 with 5M hydrochloric acid and extract with ethyl acetate. Separate the layers and dry the organics over magnesium sulfate, filter and concentrate. The title compound is obtained as a white solid (1.58 g, 95%). MS (m/z): 385 (M+1).

Provenance & Evidence