HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 929912Generated: October 31, 2026
Hydroxyamine hydrochloride → 3,5-Difluoro-4-((hydroxyimino)methyl)benzonitrile
https://huagongshe.com/reaction/929912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | 3,5-Difluoro-4-formylbenzonitrile | HCID 16218256 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,5-Difluoro-4-((hydroxyimino)methyl)benzonitrile | HCID 90014851 | 23.3% |
Reaction Steps
A mixture of 3,5-difluoro-4-formylbenzonitrile (500 mg, 3.0 mmol), hydroxylamine hydrochloride (207 mg, 3.0 mmol) and potassium acetate (586 mg, 6.0 mmol) in methanol (10 mL) was heated to 60° C. for 1 h then concentrated in vacuo and purified by column chromatography (eluent: DCM) to afford 3,5-difluoro-4-((hydroxyimino)methyl)benzonitrile (130 mg, 0.7 mmol) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296725B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-d6c74245b79441fd9cbd77aeeca64ec0 |
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| Source note | uspto-grants-2016_03 |
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