HCID 65807613, compound → HCID 90023132, compound

Participants

Reaction Steps

A mixture of N—((S)-1-hydroxypropan-2-yl)-2-(4-nitro-1H-pyrazol-1-yl)acetamide (4 g, 17.5 mmol) and 10% Pd/C (500 mg) in THF (50 mL) was stirred overnight at room temperature under a hydrogen atmosphere. The Pd/C was removed through filtration and the filtrate was concentrated in vacuo to afford (S)-2-(4-amino-1H-pyrazol-1-yl)-N-(1-hydroxypropan-2-yl)acetamide V-1 (3.5 g, 100%) as a grey solid which was used without further purification.

Provenance & Evidence