2-(4-nitro-1H-pyrazol-1-yl)-N-(propan-2-yl)acetamide → 2-(4-amino-1H-pyrazol-1-yl)-N-isopropylacetamide

Participants

Reaction Steps

A mixture of N-isopropyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide (12 g, 56.5 mmol) and Pd/C (1 g) in THF (100 mL) was stirred at room temperature under an atmosphere of hydrogen for 5 h then filtered over Celite. The filtrate was concentrated in vacuo to afford 2-(4-amino-1H-pyrazol-1-yl)-N-isopropylacetamide V-3 (10.3 g, 100%). LC-MS (Method A), RT=1.42 min. (ES+) 183.

Provenance & Evidence