1-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)pyrrolidin-2-one → HCID 62138823, compound

HRID 929923Notes

Reaction equation

HRID 929923 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:8]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:8]=1

Participants

4

Reactant 1

HCID 900243501-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)pyrrolidin-2-one

Product 1

HCID 62138823HCID 62138823, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)pyrrolidin-2-one (0.21 g, 0.9 mmol) and Pd/C (50 mg) in ethanol (20 mL) was stirred overnight at room temperature under an atmosphere of hydrogen then filtered over Celite. The filtrate was concentrated in vacuo to afford 1-(2-(4-amino-1H-pyrazol-1-yl)ethyl)pyrrolidin-2-one V-5 (0.19 g, 100%) as a purple oil. LC-MS (Method C), RT=0.38 min. (ES+) 195.

Workup

  1. filtrationthen filtered over Celite
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-94cc87e051f544a9a273024999efe739
Source dataset
uspto-grants-2016_03
Patent number
US09296725B2

Reaction notes

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