3-Hydrazinylpyridine hydrochloride → HCID 89602438, compound

HRID 930001Notes

Reaction equation

HRID 930001 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=CN=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[N:24]1C=CC=C(NN)[CH:25]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:25]=[N:24][CH:17]=[CH:18][CH:19]=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 231434543-Hydrazinylpyridine hydrochlorideHCID 896025755-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 89602438HCID 89602438, compound

Procedure

807 mg (2.90 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 464 mg (3.19 mmol) of 3-pyridylhydrazine hydrochloride. After hydrolysis, 353 mg (38% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-58ea4d4ef55f425e82b68b610a9566a8
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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