4-Chloropyridin-3-yl-hydrazine dihydrochloride → HCID 89610057, compound

HRID 930002Notes

Reaction equation

HRID 930002 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=CN=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:23].Cl.ClC1C=C[N:29]=[CH:28]C=1NN>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:28]=[N:29][C:17]([Cl:23])=[CH:18][CH:19]=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 896017534-Chloropyridin-3-yl-hydrazine dihydrochlorideHCID 89602575HCID 89602575, compound

Product 1

HCID 89610057HCID 89610057, compound

Procedure

1.21 g (4.35 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 1.04 g (4.78 mmol) of 4-chloropyridin-3-yl-hydrazine dihydrochloride. After hydrolysis, 220 mg (14% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-4f0cb15859f748ddb411b3b7bc26cf95
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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