HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydrazinyl-2-methylpyridine--hydrogen chloride (1/1) → 5-(3-Chloro-5-fluorophenyl)-1-(6-methylpyridin-3-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydrazinyl-2-methylpyridine--hydrogen chloride (1/1) | HCID 24820511 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Product | 5-(3-Chloro-5-fluorophenyl)-1-(6-methylpyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602560 | — |
Reaction Steps
785 g (2.25 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 599 mg (3.38 mmol) of 6-methylpyridin-3-yl-hydrazine hydrochloride. After hydrolysis, 60 mg (8% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-5d5f077b4bf74f618941508267f13513 |
| Source note | uspto-grants-2016_03 |