Ammonia → 5-(3-Chloro-5-fluorophenyl)-1-(6-aminopyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Participants

Reaction Steps

70 mg (80%, 0.16 mmol) of the compound of Example 23A is mixed with ammonia solution (14 N, 1.5 ml) and kept in the microwave in a sealed tube for 13 hours at 150° C., whereby a pressure of 20 bar develops. After cooling to room temperature, the ammonia solution is removed i. vac., and the residue is purified via preparative HPLC (mobile solvent: acetonitrile/water gradient). 20 mg (38% of theory) of the title compound is obtained.

Provenance & Evidence