5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid → HCID 89609998, compound

HRID 930005Notes

Reaction equation

HRID 930005 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2N(C3C=CC=CN=3)N=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[Cl:24][C:25]1[CH:26]=[C:27]([NH:31][NH2:32])[CH:28]=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:31]([C:27]3[CH:28]=[N:29][CH:30]=[C:25]([Cl:24])[CH:26]=3)[N:32]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 896025755-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acidHCID 118006407HCID 118006407, compound

Product 1

HCID 89609998HCID 89609998, compound

Procedure

785 mg (2.25 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 608 mg (3.38 mmol) of 5-chloropyridin-3-yl-hydrazine hydrochloride. After hydrolysis, 270 mg (34% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-bc6d2b704b654400bdad789c84806736
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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