HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydrazinylpyridine dihydrochloride → 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydrazinylpyridine dihydrochloride | HCID 23014179 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Product | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602493 | — |
Reaction Steps
1.30 g (3.97 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 1.08 g (5.95 mmol) of 4-pyridylhydrazine dihydrochloride. After hydrolysis, 9 mg (0.7% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-61c549b8ff924b1f8fff017dd4b83f7d |
| Source note | uspto-grants-2016_03 |