HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydrazino-2-methylpyridine hydrobromide → 5-(3-Chloro-5-fluorophenyl)-1-(2-methylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydrazino-2-methylpyridine hydrobromide | HCID 50999449 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Product | 5-(3-Chloro-5-fluorophenyl)-1-(2-methylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602617 | — |
Reaction Steps
500 mg (1.53 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 342 mg (1.68 mmol) of 2-methylpyridin-4-yl-hydrazine hydrobromide. After hydrolysis, 425 mg (84% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c114c7e705f44af6af41606cd1d11519 |
| Source note | uspto-grants-2016_03 |