HCID 89602575, compound → HCID 89602587, compound

HRID 930010Notes

Reaction equation

HRID 930010 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18]C=CN=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[CH3:24][O:25][C:26]1[CH:31]=C(NN)C=C[N:27]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][N:27]=[C:26]([O:25][CH3:24])[CH:31]=3)[N:12]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 89602575HCID 89602575, compoundHCID 118006398HCID 118006398, compound

Product 1

HCID 89602587HCID 89602587, compound

Procedure

500 mg (1.53 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 295 mg (1.68 mmol) of 2-methoxypyridin-4-yl-hydrazine hydrochloride. After hydrolysis, 8 mg (1.5% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-4261ac7794b1493c8075164317d329e9
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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