HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydrazinylpyridine hydrochloride → 5-(3-Bromo-5-fluorophenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydrazinylpyridine hydrochloride | HCID 23143454 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Reactant | Lithium 1-(3-bromo-5-fluorophenyl)-4-ethoxy-3,4-dioxobut-1-en-1-olate | HCID 131735130 | — |
| Product | 5-(3-Bromo-5-fluorophenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602590 | — |
Reaction Steps
600 mg (1.30 mmol) of the compound of Example 2A is reacted analogously to the synthesis of the compound of Example 20A with 208 mg (1.43 mmol) of 3-pyridylhydrazine hydrochloride. After hydrolysis, 406 mg (86% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-725aff4297ea48938c209565721c60d0 |
| Source note | uspto-grants-2016_03 |