2-hydrazinylpyridine hydrochloride → HCID 89602484, compound

HRID 930014Notes

Reaction equation

HRID 930014 reaction equation
[Li].[Br:2][C:3]1[CH:4]=[C:5]([C:14]([O-])=[CH:15][C:16](=O)[C:17]([O:19]CC)=[O:18])[CH:6]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:8]=1.ClC1C=C(C2[N:36]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=3)[N:35]=C(C(O)=O)C=2)C=C(F)C=1.Cl.N1C=CC=CC=1NN>>[Br:2][C:3]1[CH:4]=[C:5]([C:14]2[N:36]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=3)[N:35]=[C:16]([C:17]([OH:19])=[O:18])[CH:15]=2)[CH:6]=[C:7]([O:9][C:10]([F:11])([F:12])[F:13])[CH:8]=1

Participants

4

Reactant 3

HCID 5213152-hydrazinylpyridine hydrochlorideHCID 896025755-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acidHCID 131734661HCID 131734661, compound

Product 1

HCID 89602484HCID 89602484, compound

Procedure

1.10 g (2.40 mmol) of the compound of Example 5A is reacted analogously to the synthesis of the compound of Example 20A with 525 mg (3.61 mmol) of 2-pyridylhydrazine hydrochloride. After hydrolysis, 557 mg (54% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-b1e362502f2c4f6fb938f08af78af470
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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