HCID 89602575, compound → HCID 89610051, compound

HRID 930026Notes

Reaction equation

HRID 930026 reaction equation
[Li].[Br:2][C:3]1[CH:4]=[C:5]([C:14]([O-])=[CH:15][C:16](=O)[C:17]([O:19]CC)=[O:18])[CH:6]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:8]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.[CH3:47][O:48][C:49]1[CH:54]=[C:53]([NH:55][NH2:56])[CH:52]=[CH:51][N:50]=1>>[Br:2][C:3]1[CH:4]=[C:5]([C:14]2[N:55]([C:53]3[CH:52]=[CH:51][N:50]=[C:49]([O:48][CH3:47])[CH:54]=3)[N:56]=[C:16]([C:17]([OH:19])=[O:18])[CH:15]=2)[CH:6]=[C:7]([O:9][C:10]([F:11])([F:12])[F:13])[CH:8]=1

Participants

4

Reactant 3

HCID 89602575HCID 89602575, compoundHCID 118006398HCID 118006398, compoundHCID 131734661HCID 131734661, compound

Product 1

HCID 89610051HCID 89610051, compound

Procedure

500 mg (1.16 mmol) of the compound of Example 5A is reacted analogously to the synthesis of the compound of Example 20A with 305 mg (1.74 mmol) of 2-methoxypyridin-4-yl-hydrazine hydrochloride. After hydrolysis, 18 mg (3% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-2448bb92e20a431e86032c88335f691b
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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