HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-hydrazinylpyridine hydrochloride → 5-(3-Bromo-5-methoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-hydrazinylpyridine hydrochloride | HCID 86593839 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Reactant | Lithium 1-(3-bromo-5-methoxyphenyl)-4-ethoxy-3,4-dioxobut-1-en-1-olate | HCID 131735132 | — |
| Product | 5-(3-Bromo-5-methoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602472 | — |
Reaction Steps
500 mg (1.19 mmol) of the compound of Example 6A is reacted analogously to the synthesis of the compound of Example 20A with 322 mg (1.79 mmol) of 2-chloropyridin-4-yl-hydrazine hydrochloride. After hydrolysis, 259 mg (53% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-3b91cddfafe249ac845f1fccb4f483a8 |
| Source note | uspto-grants-2016_03 |