3-Hydrazinylpyridine hydrochloride → HCID 89602592, compound

HRID 930032Notes

Reaction equation

HRID 930032 reaction equation
[Li].[Br:2][C:3]1[CH:4]=[C:5]([C:13]([O-])=[CH:14][C:15](=O)[C:16]([O:18]CC)=[O:17])[CH:6]=[C:7]([O:9][CH:10]([F:12])[F:11])[CH:8]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.[N:46]1[CH:51]=[CH:50][CH:49]=[C:48]([NH:52][NH2:53])[CH:47]=1>>[Br:2][C:3]1[CH:4]=[C:5]([C:13]2[N:52]([C:48]3[CH:47]=[N:46][CH:51]=[CH:50][CH:49]=3)[N:53]=[C:15]([C:16]([OH:18])=[O:17])[CH:14]=2)[CH:6]=[C:7]([O:9][CH:10]([F:11])[F:12])[CH:8]=1

Participants

4

Reactant 3

HCID 231434543-Hydrazinylpyridine hydrochlorideHCID 89602575HCID 89602575, compoundHCID 131735135HCID 131735135, compound

Product 1

HCID 89602592HCID 89602592, compound

Procedure

247 mg (0.67 mmol) of the compound of Example 9A is reacted analogously to the synthesis of the compound of Example 20A with 145 mg (1.00 mmol) of 3-pyridylhydrazine hydrochloride. After hydrolysis, 51 mg (19% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-c63b7e911b4d4ab1b29333d9d7f9905f
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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