3-Hydrazinylpyridine hydrochloride → HCID 89602419, compound

HRID 930035Notes

Reaction equation

HRID 930035 reaction equation
[Li].[C:2]([C:4]1[CH:5]=[C:6]([C:15]([O-])=[CH:16][C:17](=O)[C:18]([O:20]CC)=[O:19])[CH:7]=[C:8]([O:10][C:11]([F:14])([F:13])[F:12])[CH:9]=1)#[N:3].ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.[N:48]1[CH:53]=[CH:52][CH:51]=[C:50]([NH:54][NH2:55])[CH:49]=1>>[C:2]([C:4]1[CH:5]=[C:6]([C:15]2[N:54]([C:50]3[CH:49]=[N:48][CH:53]=[CH:52][CH:51]=3)[N:55]=[C:17]([C:18]([OH:20])=[O:19])[CH:16]=2)[CH:7]=[C:8]([O:10][C:11]([F:12])([F:13])[F:14])[CH:9]=1)#[N:3]

Participants

4

Reactant 3

HCID 231434543-Hydrazinylpyridine hydrochlorideHCID 89602575HCID 89602575, compoundHCID 131735137HCID 131735137, compound

Product 1

HCID 89602419HCID 89602419, compound

Procedure

300 mg (0.81 mmol) of the compound of Example 11A is reacted analogously to the synthesis of the compound of Example 20A with 175 mg (1.21 mmol) of 3-pyridylhydrazine hydrochloride. After hydrolysis, 148 mg (49% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-697f12a60979439e862c7d77d5ff9dc2
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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