HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chlorophenylhydrazine hydrochloride → 1-(3-Chlorophenyl)-5-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Reactant | Lithium 1-(2-chloropyridin-4-yl)-4-ethoxy-3,4-dioxobut-1-en-1-olate | HCID 131735144 | — |
| Product | 1-(3-Chlorophenyl)-5-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602442 | — |
Reaction Steps
560 mg (2.14 mmol) of the compound of Example 19A is reacted analogously to the synthesis of the compound of Example 20A with 422 mg (2.36 mmol) of 3-chlorophenylhydrazine hydrochloride. After hydrolysis, 494 mg (69% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bf5abfd5c98b43b89ed41cd52e4302a4 |
| Source note | uspto-grants-2016_03 |