HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 71576484, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66687731 | HCID 66687731 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602575 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 71576484 | HCID 71576484 | — |
Reaction Steps
0.12 ml (0.71 mmol) of N,N-diisopropylethylamine as well as 0.5 ml of DMF are added to a solution of 75 mg (0.24 mmol) of the compound of Example 20A, 32 mg (0.26 mmol) of 4-imidazolinone-hydrochloride, and 126 mg (0.33 mmol) of HATU in 1 ml of THF, and the mixture that is obtained is stirred for 16 hours at room temperature. The reaction mixture is diluted with acetonitrile, filtered over a Millipore spray filter, and separated by means of preparative HPLC (mobile solvent: acetonitrile/water gradient). 71 mg (78% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-0372d39e359e428888b7e7cf0b2c5330 |
| Source note | uspto-grants-2016_03 |