HCID 66687731, compound → 1-[5-(3-Chloro-5-fluoro-phenyl)-1-(5-chloro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930052Notes

Reaction equation

HRID 930052 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([Cl:20])[CH:19]=3)[N:12]=[C:11]([C:21](O)=[O:22])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([Cl:20])[CH:19]=3)[N:12]=[C:11]([C:21]([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=[O:22])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 89609998HCID 89609998, compound

Product 1

HCID 715765381-[5-(3-Chloro-5-fluoro-phenyl)-1-(5-chloro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

75 mg (0.21 mmol) of the compound of Example 26A is reacted analogously to the synthesis of the compound of Example 1 with 29 mg (0.23 mmol) of 4-imidazolinone-hydrochloride. 74 mg (82% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-3ea909a81fae419d8c5ff0111a5c1904
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

Loading…