HCID 66687731, compound → 1-[5-(3-Chloro-5-fluoro-phenyl)-1-(6-methyl-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930054Notes

Reaction equation

HRID 930054 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=3)[N:12]=[C:11]([C:21]([OH:23])=O)[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=3)[N:12]=[C:11]([C:21]([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=[O:23])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 896025605-(3-Chloro-5-fluorophenyl)-1-(6-methylpyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 715765841-[5-(3-Chloro-5-fluoro-phenyl)-1-(6-methyl-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

57 mg (0.17 mmol) of the compound of Example 24A is reacted analogously to the synthesis of the compound of Example 1 with 23 mg (0.19 mmol) of 4-imidazolinone-hydrochloride. 58 mg (84% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-2c7f33353b794f5fa74955dd22976b87
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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