HCID 66687731, compound → HCID 71576586, compound

HRID 930055Notes

Reaction equation

HRID 930055 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[N:12]=[C:11]([C:20]([OH:22])=O)[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:44]3[CH2:48][C:47](=[O:49])[NH:46][CH2:45]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[N:12]=[C:11]([C:20]([N:44]3[CH2:48][C:47](=[O:49])[NH:46][CH2:45]3)=[O:22])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 896024935-(3-Chloro-5-fluorophenyl)-1-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 71576586HCID 71576586, compound

Procedure

9 mg (0.03 mmol) of the compound of Example 27A is reacted analogously to the synthesis of the compound of Example 1 with 4 mg (0.03 mmol) of 4-imidazolinone-hydrochloride. 4 mg (35% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-a1c377df80044f2c865114e61de96c32
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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