HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(2-methyl-4-pyridyl)pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 71576533 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-1-(2-methylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602617 | — |
| Product | 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(2-methyl-4-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 86574283 | — |
Reaction Steps
75 mg (0.23 mmol) of the compound of Example 30A is reacted analogously to the synthesis of the compound of Example 4 with 24 mg (0.24 mmol) of 2-oxopiperazine. 77 mg (82% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f179fd85fb5141bb87dcc90bb4eb15c6 |
| Source note | uspto-grants-2016_03 |