m-Chloroperbenzoic acid → [5-(3-Chloro-5-fluoro-phenyl)-1-(2-methyl-4-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	m-Chloroperbenzoic acid	HCID 70297	—
Reactant	[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone	HCID 71576535	—
Reactant	[5-(3-Chloro-5-fluoro-phenyl)-1-(2-methyl-4-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone	HCID 86574284	—
Product	[5-(3-Chloro-5-fluoro-phenyl)-1-(2-methyl-4-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone	HCID 86574285	—

Reaction Steps

55 mg (0.14 mmol) of the compound of Example 23 is reacted analogously to the synthesis of the compound of Example 6 with 34 mg (0.14 mmol, 70%) of meta-chloroperbenzoic acid for 2 hours at room temperature. After the crude product is purified by means of preparative HPLC (mobile solvent: acetonitrile/water gradient), 53 mg (93% of theory) of the title compound is obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09296720B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-02dc80c9699f4fbb8750474eadaf3b91
Source note	uspto-grants-2016_03