Piperazin-2-one → 4-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one

Participants

Reaction Steps

75 mg (0.16 mmol) of the compound of Example 39A is reacted analogously to the synthesis of the compound of Example 4 with 17 mg (0.17 mmol) of 2-oxopiperazine. 21 mg (25% of theory) of the title compound is obtained as a fine precipitate as well as 37 mg (46% of theory) of the title compound after the filtrate is purified by means of preparative HPLC (mobile solvent: acetonitrile/water gradient).

Provenance & Evidence