HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 71576533 | — |
| Reactant | HCID 89609966 | HCID 89609966 | — |
| Product | 4-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 86574251 | — |
Reaction Steps
75 mg (0.14 mmol, 84% purity) of the compound of Example 40A is reacted analogously to the synthesis of the compound of Example 4 with 15 mg (0.15 mmol) of 2-oxopiperazine. 56 mg (75% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4fb997d9d06141e887cec875b98d1cab |
| Source note | uspto-grants-2016_03 |