HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidine → [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidine | HCID 10444 | — |
| Reactant | 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 71576533 | — |
| Reactant | HCID 89609966 | HCID 89609966 | — |
| Product | [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone | HCID 86574252 | — |
Reaction Steps
170 mg (0.28 mmol, 76% purity) of the compound of Example 40A is reacted analogously to the synthesis of the compound of Example 4 with 27 mg (0.30 mmol) of thiazolidine. 96 mg (62% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-e4fb8589601a431eb783a9c7694deeab |
| Source note | uspto-grants-2016_03 |