HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | [5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone | HCID 71576535 | — |
| Reactant | [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone | HCID 86574252 | — |
| Product | [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-chloro-3-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone | HCID 86574253 | — |
Reaction Steps
38 mg (0.07 mmol) of the compound of Example 36 is reacted analogously to the synthesis of the compound of Example 6 with 18 mg (0.07 mmol, 70%) of meta-chloroperbenzoic acid for 72 hours at room temperature. After the crude product is purified by means of preparative HPLC (mobile solvent: acetonitrile/water gradient), 31 mg (79% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-726ee56e8e104a7bb06174a1db4d33be |
| Source note | uspto-grants-2016_03 |