HCID 66687731, compound → 1-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(5-fluoro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930073Notes

Reaction equation

HRID 930073 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[C:22]([F:24])[CH:23]=3)[N:16]=[C:15]([C:25]([OH:27])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[C:22]([F:24])[CH:23]=3)[N:16]=[C:15]([C:25]([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=[O:27])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:10])([F:12])[F:11])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 89609968HCID 89609968, compound

Product 1

HCID 865746221-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(5-fluoro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

75 mg (0.17 mmol) of the compound of Example 44A is reacted analogously to the synthesis of the compound of Example 1 with 23 mg (0.19 mmol) of 4-imidazolinone-hydrochloride. 71 mg (82% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-8c23914e836a4b389525580de50e2e70
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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