HCID 66687731, compound → 1-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930078Notes

Reaction equation

HRID 930078 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)[N:16]=[C:15]([C:28](O)=[O:29])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(N3CC(=O)NC3)=[O:51])C=2)C=C(F)C=1.Cl.[NH:59]1[CH:63]=[CH:62][NH:61][C:60]1=O>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:24]([F:26])([F:27])[F:25])[CH:19]=3)[N:16]=[C:15]([C:28]([N:59]3[CH2:63][C:62](=[O:51])[NH:61][CH2:60]3)=[O:29])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:10])([F:11])[F:12])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 896100545-(3-Bromo-5-trifluoromethoxyphenyl)-1-(2-trifluoromethylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 865746401-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

75 mg (0.15 mmol) of the compound of Example 47A is reacted analogously to the synthesis of the compound of Example 1 with 20 mg (0.17 mmol) of 4-imidazolinone-hydrochloride. 72 mg (84% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-ab490fa95e974ee4a5ba51ad56baa13f
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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