HCID 66687731, compound → 1-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(2-methyl-4-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930079Notes

Reaction equation

HRID 930079 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)[N:16]=[C:15]([C:25]([OH:27])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)[N:16]=[C:15]([C:25]([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=[O:27])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 896099325-(3-Bromo-5-trifluoromethoxyphenyl)-1-(2-methylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 865746431-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(2-methyl-4-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

75 mg (0.17 mmol) of the compound of Example 48A is reacted analogously to the synthesis of the compound of Example 1 with 23 mg (0.19 mmol) of 4-imidazolinone-hydrochloride. 72 mg (83% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-9772bbb8d20d4450bb9f3439d390a9d5
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

Loading…