HCID 66687731, compound → HCID 86574654, compound

HRID 930081Notes

Reaction equation

HRID 930081 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([O:24][CH3:25])[CH:19]=3)[N:16]=[C:15]([C:26]([OH:28])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:50]3[CH2:54][C:53](=[O:55])[NH:52][CH2:51]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([O:24][CH3:25])[CH:19]=3)[N:16]=[C:15]([C:26]([N:50]3[CH2:54][C:53](=[O:55])[NH:52][CH2:51]3)=[O:28])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:10])[F:11])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 89610051HCID 89610051, compound

Product 1

HCID 86574654HCID 86574654, compound

Procedure

18 mg (0.04 mmol) of the compound of Example 49A is reacted analogously to the synthesis of the compound of Example 1 with 5 mg (0.04 mmol) of 4-imidazolinone-hydrochloride. 4 mg (14% of theory, 82% purity) of the title compound is obtained.

Sources & evidence

ORD record
ord-56d6407af50e4af886b23ff0abc00a71
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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