Piperazin-2-one → HCID 86574671, compound

HRID 930086Notes

Reaction equation

HRID 930086 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([Cl:24])[CH:19]=3)[N:16]=[C:15]([C:25]([OH:27])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=NC=CC=3)N=C(C([N:49]3[CH2:54][CH2:53][NH:52][C:51](=[O:55])[CH2:50]3)=O)C=2)C=C(F)C=1.O=C1CNCCN1>>[Cl:24][C:20]1[CH:19]=[C:18]([N:17]2[C:13]([C:4]3[CH:5]=[C:6]([O:8][C:9]([F:10])([F:11])[F:12])[CH:7]=[C:2]([F:1])[CH:3]=3)=[CH:14][C:15]([C:25]([N:49]3[CH2:54][CH2:53][NH:52][C:51](=[O:55])[CH2:50]3)=[O:27])=[N:16]2)[CH:23]=[CH:22][N:21]=1

Participants

4

Reactant 3

HCID 231360Piperazin-2-oneHCID 715765334-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-oneHCID 89609965HCID 89609965, compound

Product 1

HCID 86574671HCID 86574671, compound

Procedure

40 mg (0.08 mmol) of the compound of Example 35A is reacted analogously to the synthesis of the compound of Example 4 with 8 mg (0.08 mmol) of 2-oxopiperazine. 27 mg (71% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-7423faf60e2645ae98b52f08ee22fb29
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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