HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[1-(2-Chloro-4-pyridyl)-5-[3-(difluoromethoxy)-5-fluoro-phenyl]pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 71576533 | — |
| Reactant | 5-(3-Fluoro-5-difluoromethoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89609957 | — |
| Product | 4-[1-(2-Chloro-4-pyridyl)-5-[3-(difluoromethoxy)-5-fluoro-phenyl]pyrazole-3-carbonyl]piperazin-2-one | HCID 86574263 | — |
Reaction Steps
40 mg (0.10 mmol) of the compound of Example 53A is reacted analogously to the synthesis of the compound of Example 4 with 11 mg (0.11 mmol) of 2-oxopiperazine. 39 mg (80% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bea88e0329b14553beb5b1f69399e789 |
| Source note | uspto-grants-2016_03 |