Thiazolidine → [5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

HRID 930089Notes

Reaction equation

HRID 930089 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([OH:26])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.[S:27]1[CH2:31][CH2:30][NH:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:29]3[CH2:30][CH2:31][S:27][CH2:28]3)=[O:26])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:11])([F:12])[F:10])[CH:7]=1

Participants

3

Reactant 2

HCID 10444ThiazolidineHCID 896024635-(3-Chloro-5-trifluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 86574628[5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

Procedure

120 mg (0.31 mmol) of the compound of Example 36A is reacted analogously to the synthesis of the compound of Example 3 with 30 mg (0.34 mmol) of thiazolidine. 86 mg (60% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-04dc4a4d1daf49d0947fea98db56c214
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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