HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[1-(2-Chloro-4-pyridyl)-5-[3-methoxy-5-(trifluoromethoxy)phenyl]pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 4-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 71576533 | — |
| Reactant | 5-(3-Methoxy-5-trifluoromethoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602837 | — |
| Product | 4-[1-(2-Chloro-4-pyridyl)-5-[3-methoxy-5-(trifluoromethoxy)phenyl]pyrazole-3-carbonyl]piperazin-2-one | HCID 86574648 | — |
Reaction Steps
31 mg (0.08 mmol) of the compound of Example 57A is reacted analogously to the synthesis of the compound of Example 4 with 8 mg (0.08 mmol) of 2-oxopiperazine. 37 mg (99% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-60594542e0e14e0bb67ad7ee7655e07c |
| Source note | uspto-grants-2016_03 |