Piperazin-2-one → HCID 86574660, compound

HRID 930095Notes

Reaction equation

HRID 930095 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:14]2[N:18]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[N:17]=[C:16]([C:25](O)=[O:26])[CH:15]=2)[CH:6]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:8]=1)#[N:2].ClC1C=C(C2N(C3C=CC=CN=3)N=C([C:47]([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=O)C=2)C=C(F)C=1.O=C1CNCCN1>>[O:54]=[C:52]1[NH:51][CH2:50][CH2:47][N:49]([C:25]([C:16]2[CH:15]=[C:14]([C:5]3[CH:4]=[C:3]([CH:8]=[C:7]([O:9][C:10]([F:12])([F:13])[F:11])[CH:6]=3)[C:1]#[N:2])[N:18]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[N:17]=2)=[O:26])[CH2:53]1

Participants

4

Reactant 3

HCID 231360Piperazin-2-oneHCID 71576484HCID 71576484, compoundHCID 89602419HCID 89602419, compound

Product 1

HCID 86574660HCID 86574660, compound

Procedure

30 mg (0.08 mmol) of the compound of Example 58A is reacted analogously to the synthesis of the compound of Example 1 with 9 mg (0.09 mmol) of 2-oxopiperazine. 30 mg (83% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-6eafffe7fe6f44a7a2ed658d4d2d3803
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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