HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[5-(3-Bromo-5-methoxy-phenyl)-1-(2-chloro-4-pyridyl)pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | HCID 71576484 | HCID 71576484 | — |
| Reactant | 5-(3-Bromo-5-methoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602472 | — |
| Product | 4-[5-(3-Bromo-5-methoxy-phenyl)-1-(2-chloro-4-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 86574290 | — |
Reaction Steps
50 mg (0.12 mmol) of the compound of Example 51A is reacted analogously to the synthesis of the compound of Example 1 with 13 mg (0.14 mmol) of 2-oxopiperazine. 50 mg (84% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-40d1de9a174040fb97c60cdb6717ba01 |
| Source note | uspto-grants-2016_03 |