HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[1-(3-Chloro-4-fluoro-phenyl)-5-(5-fluoro-3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 1-[1-(3-Chloro-4-fluoro-phenyl)-5-(5-fluoro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one | HCID 86574291 | — |
| Reactant | 1-(3-Chloro-4-fluorophenyl)-5-(5-fluoropyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89609959 | — |
| Product | 4-[1-(3-Chloro-4-fluoro-phenyl)-5-(5-fluoro-3-pyridyl)pyrazole-3-carbonyl]piperazin-2-one | HCID 86574292 | — |
Reaction Steps
100 mg (0.30 mmol) of the compound of Example 60A is reacted analogously to the synthesis of the compound of Example 98 with 33 mg (0.33 mmol) of 2-oxopiperazine. 92 mg (74% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-acc02698418b4becbf028f1a8bdd4c63 |
| Source note | uspto-grants-2016_03 |