HCID 66687731, compound → 1-[1-(3-Chloro-4-fluoro-phenyl)-5-(5-chloro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930104Notes

Reaction equation

HRID 930104 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([Cl:20])[CH:19]=3)=[CH:12][C:11]([C:21]([OH:23])=O)=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(N2C(C3C=NC=C(F)C=3)=CC(C([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=O)=N2)C=CC=1F.Cl.N1C=CNC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([Cl:20])[CH:19]=3)=[CH:12][C:11]([C:21]([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=[O:23])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 865742911-[1-(3-Chloro-4-fluoro-phenyl)-5-(5-fluoro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-oneHCID 896099741-(3-Chloro-4-fluorophenyl)-5-(5-chloropyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 865743051-[1-(3-Chloro-4-fluoro-phenyl)-5-(5-chloro-3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

100 mg (0.28 mmol) of the compound of Example 61A is reacted analogously to the synthesis of the compound of Example 98 with 38 mg (0.31 mmol) of 4-imidazolinone-hydrochloride. 62 mg (52% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-10ca6aa7ac824fc29be13a3d940674f4
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

Loading…