HCID 66687731, compound → HCID 86574329, compound

HRID 930110Notes

Reaction equation

HRID 930110 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:14]=[N:15][C:16]([F:20])=[C:17]([Cl:19])[CH:18]=3)=[CH:11][C:10]([C:21]([OH:23])=O)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Cl:19][C:17]1[CH:18]=[C:13]([C:12]2[N:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:9]=[C:10]([C:21]([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=[O:23])[CH:11]=2)[CH:14]=[N:15][C:16]=1[F:20]

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 89609975HCID 89609975, compound

Product 1

HCID 86574329HCID 86574329, compound

Procedure

21 mg (0.06 mmol) of the compound of Example 63A is reacted analogously to the synthesis of the compound of Example 1 with 8 mg (0.07 mmol) of 4-imidazolinone-hydrochloride. 15 mg (59% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-254ca6b6da7440f2bcfbf37ec11780a8
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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