HCID 66687731, compound → HCID 86574330, compound

HRID 930111Notes

Reaction equation

HRID 930111 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:15]=[N:16][C:17]([F:21])=[C:18]([Cl:20])[CH:19]=3)=[CH:12][C:11]([C:22](O)=[O:23])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:15]=[N:16][C:17]([F:21])=[C:18]([Cl:20])[CH:19]=3)=[CH:12][C:11]([C:22]([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=[O:23])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 89610063HCID 89610063, compound

Product 1

HCID 86574330HCID 86574330, compound

Procedure

16 mg (0.04 mmol) of the compound of Example 62A is reacted analogously to the synthesis of the compound of Example 1 with 6 mg (0.05 mmol) of 4-imidazolinone-hydrochloride. 11 mg (55% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-f0c11b432c934ee38cb87a65b4811a0d
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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